The potential of fucoidan extract in stimulating the growth of osteoblast cells on alveolar bonepotential of fucoidan extract in stimulating the growth of osteoblast cells on alveolar bone

Potensi ekstrak fucoidan dalam merangsang pertumbuhan osteoblas pada tulang alveolar

Abstract

Alveolar bone is mineralized connective tissue with cellular components consisting of three main cell types: osteoblasts, osteo-cytes, and osteoclasts. Alveolar bone conditions can undergo resorption due to certain conditions such as bacterial invasion due to periodontal disease. Fucoidan can increase alkaline phosphate levels, collagen type-1 expression, osteocalcin, and BMP-2 and assist in mineral deposition associated with bone healing through increased osteoblasts.This review is a descriptive obser-vation through systematic and structured literature searches through PubMed, Elsevier (Scopus), Science Direct, Springer, and Jurn websites. As many 1,482 articles found, they were filtered and found as many as 5 reference articles. It is concluded that fucoidan extract can stimulate the growth of osteoblast cells with the speed of growth of osteoblast cells depending on the con-centration and amount of fucoidan given